Endocrine Abstracts

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...

Aim/introduction: The main purpose of this work was to describe a clinical case of thyrotoxicosis with concomitant HASHARON hemoglobinopathy scrutinizing whether the latter could hinder radioiodine therapy (RIT).Materials and methods: Patient H., 53 years old, diagnosed with moderate toxic diffuse multinodular goiter. Clinical manifestation of the disease were in summer 2018 (TSH – 0 mIU/ml). Medication with thyrozole (20 mg) was initiated. Thyroto...

Prospective non-comparable randomized clinical investigation of GH/IGH-1 control and tumor growth reduction in active acromegalic patients on Octreotide-LAR is presented. Fifty patients (pts) with newly diagnosed acromegaly (primary teratment, group 1; mean age 47.8±13.9 years old) and 39 pts after previous surgical and/or radiological treatment (secondary treatment, group 2; mean age 48.1±12.2 years old) were treated with Ocrteotide LAR 20–40 mg every 4 weeks, ...

Purpose : To determine the effective and safe regimen of glucocorticoids administration in patients with COVID-19 and with or without DM.Materials and methods: We examined 276 patients with covid-19 and polysegmental pneumonia with CT (1-4) in inpatient treatment with an oxygen support level of up to 15 liters per minute, all patients were discharged from the hospital. Patients were divided into 2 groups according to the therapy they received. The first ...

Introduction: Connshing syndrome is a rare disease characterized by mixed overproduction of mineralocorticoids and glucocorticoids from adrenal adenoma. We will describe a clinical case that illustrates a rare combination of aldosterone-cortisol co-secreting formation of the left adrenal gland against a background of bilateral macronodular adrenal hyperplasia, and the role of diagnostic methods in determining appropriate tactics for patient treatment.Cas...

Foreign bodies represent a rare cause of granulomatous mastitis. In the last three years we diagnosed three women with granulomatous mastitis consecutive to exposure at building materials containing glass fibers. All of them were young (21–34 years), with regular menses, without any pathological histories and were admitted to our hospital for bilateral galactorrhea spontaneous in one case and by squeezing the nipple in the other two cases. Clinical and ultrasonographic ev...

Introduction: Hashimoto’s Encephalopathy (HE) is an autoimmune inflammatory disease of the brain associated with the production of antithyroid antibodies.Objective: A clinical case of treatment of severe autoimmune encephalopathy in combination with autoimmune thyroiditis and thyrotoxicosis is presented.Results: A 59-year-old woman was transferred to the intensive care unit diagnosed with thyrotoxic crisis. Objectively: serio...

Acromegaly (A) is associated with the bone overgrowth and soft tissue abnormalities due to anabolic, lipolytic and sodium retaining actions of GH.Aim: To investigate the effects of medical treatment on bone mineral density (BMD) of proximal femur, lumbar spine and tissue distribution. We observed 56 patients (14 M and 42 F) with A. BMD was measured using dual-energy X-ray absorptiometry with ‘total body’ program. The patients were treated with ...

In our study we included retrospective analyses of 101 patients (mean age 35 years, 85 women and 16 men) with Cushing’s disease (CD), who underwent transsphenoidal surgery (TSS) treatment. CD is based on clinical suspicion, hormonal research of cortisol (F), ACTH, 24-hous urine F, results of dexamethasone suppression tests low (1 mg) dose (LDDST) and high (8 mg) dose (HDDST) and MR-imaging (MRI). Before the operation all patients have high F, ACTH, negative LDDST and posi...

Introduction: Cardiovascular disease is the commonest cause of death (absolute-excess-risk:41%) in Turner Syndrome (TS). Hypertension is a major risk for circulatory-disease (up to 60%) and a key modifiable-risk factor of aortopathy, ischemic heart disease and stroke in TS. There is no current consensus for hypertension diagnosis/management in TS.Methods: Retrospective multi-centre observational study of patients aged &#...